|Title||Apparatuses and methods for serial sectioning and imaging|
|Year of Publication||2016|
|Authors||Samuels B., Kellerson K.W, Girit B., Lukyanov A., Maloof A.C, Rozen W.|
|Assignee||Situ Studio LLC|
|Patent Number||US Patent 9,233,453|
In some embodiments, an apparatus comprises: a stage moveable on first and second axes; a material removal tool moveable on a third axis; a linear slide and a guide parallel to the third axis; a mount for an imaging device coupled to the linear slide using carriages; an armature coupled to the material removal tool and the guide that moves the guide along the third axis with the tool; a locking device for fixing the mount along the guide; and a processor that: (a) move a sample to a material removal position; (b) cause the tool to remove a first thickness of the sample along the third axis; (c) move the sample to an imaging position located at a predetermined location with respect to the mounting block; and repeating (a) through (c) until a second thickness of the sample has been removed.